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TargetProtein-S-isoprenylcysteine O-methyltransferase
LigandBDBM50327707
Substrate/Competitorn/a
Meas. Tech.ChEMBL_664824 (CHEMBL1259548)
IC50 1000±n/a nM
Citation Go, MLLeow, JLGorla, SKSchüller, APWang, MCasey, PJ Amino derivatives of indole as potent inhibitors of isoprenylcysteine carboxyl methyltransferase. J Med Chem53:6838-50 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein-S-isoprenylcysteine O-methyltransferase
Name:Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:PROTEIN
Mol. Mass.:31943.26
Organism:Homo sapiens (Human)
Description:ChEMBL_956034
Residue:284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYR
PPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLS
LDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFT
AGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTV
WRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
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  Blast E-value cutoff:
BDBM50327707
n/a
NameBDBM50327707
Synonyms:2-(1-(3,7-dimethylocta-2,6-dienyl)-5-m-tolyl-1H-indol-3-yl)acetamide | CHEMBL1258096
TypeSmall organic molecule
Emp. Form.C27H32N2O
Mol. Mass.400.5558
SMILES[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-n1cc(-[#6]-[#6](-[#7])=O)c2cc(ccc12)-c1cccc(-[#6])c1
Structure
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