Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Excitatory amino acid transporter 1 |
---|
Ligand | BDBM50328510 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_665667 (CHEMBL1261598) |
---|
IC50 | 3800±n/a nM |
---|
Citation | Erichsen, MN; Huynh, TH; Abrahamsen, B; Bastlund, JF; Bundgaard, C; Monrad, O; Bekker-Jensen, A; Nielsen, CW; Frydenvang, K; Jensen, AA; Bunch, L Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101). J Med Chem53:7180-91 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Excitatory amino acid transporter 1 |
---|
Name: | Excitatory amino acid transporter 1 |
Synonyms: | EAA1_HUMAN | EAAT1 | Excitatory Amino Acid EAAT1 | GLAST | GLAST1 | SLC1A3 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 59577.19 |
Organism: | Homo sapiens (Human) |
Description: | Excitatory Amino Acid EAAT1 0 HUMAN::P43003 |
Residue: | 542 |
Sequence: | MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM
|
|
|
BDBM50328510 |
---|
n/a |
---|
Name | BDBM50328510 |
Synonyms: | 2-Amino-5-oxo-4,7-diphenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile | CHEMBL1258989 |
Type | Small organic molecule |
Emp. Form. | C22H18N2O2 |
Mol. Mass. | 342.3905 |
SMILES | N=C1OC2=C(C(C1C#N)c1ccccc1)C(=O)CC(C2)c1ccccc1 |c:3| |
Structure |
|