| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member A1 |
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| Ligand | BDBM50251030 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_685035 (CHEMBL1286651) |
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| IC50 | 23800±n/a nM |
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| Citation |  Alexiou, P; Demopoulos, VJ A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity. J Med Chem53:7756-66 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member A1 |
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| Name: | Aldo-keto reductase family 1 member A1 |
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| Synonyms: | AK1A1_RAT | Akr1a1 | Aldehyde reductase | Alr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36509.97 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_31321 |
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| Residue: | 325 |
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| Sequence: | MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALSVGYRHIDCASVYGNETEIGEAL
KESVGAGKAVPREELFVTSKLWNTKHHPEDVEPAVRKTLADLQLEYLDLYLMHWPYAFER
GDNPFPKNADGTVKYDSTHYKETWKALEALVAKGLVKALGLSNFSSRQIDDVLSVASVRP
AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEK
HGRSPAQILLRWQVQRKVICIPKSITPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIV
PMITVDGKRVPRDAGHPLYPFNDPY
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| BDBM50251030 |
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| n/a |
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| Name | BDBM50251030 |
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| Synonyms: | CHEMBL458588 | N-(3,5-Difluoro-4-hydroxyphenyl)-4-methoxybenzenesulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C13H11F2NO4S |
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| Mol. Mass. | 315.293 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)Nc1cc(F)c(O)c(F)c1 |
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| Structure | 
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