Reaction Details |
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Target | NADPH oxidase 4 |
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Ligand | BDBM50330701 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_685143 (CHEMBL1286959) |
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Ki | 285±n/a nM |
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Citation | Laleu, B; Gaggini, F; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem53:7715-30 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NADPH oxidase 4 |
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Name: | NADPH oxidase 4 |
Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase |
Type: | PROTEIN |
Mol. Mass.: | 66954.54 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_792879 |
Residue: | 578 |
Sequence: | MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
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BDBM50330701 |
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n/a |
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Name | BDBM50330701 |
Synonyms: | 1-(2-(3-methoxyphenyl)acetyl)-4-methyl-2-phenyl-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | CHEMBL1277765 |
Type | Small organic molecule |
Emp. Form. | C28H24N4O4 |
Mol. Mass. | 480.5146 |
SMILES | COc1cccc(CC(=O)n2n(-c3ccccc3)c(=O)c3c(C)n(Cc4cccnc4)c(=O)cc23)c1 |
Structure |
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