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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | NADPH oxidase 4 | ||
| Ligand | BDBM50330702 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685143 (CHEMBL1286959) | ||
| Ki | 398±n/a nM | ||
| Citation |  Laleu, B; Gaggini, F; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem53:7715-30 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| NADPH oxidase 4 | |||
| Name: | NADPH oxidase 4 | ||
| Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 66954.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_792879 | ||
| Residue: | 578 | ||
| Sequence: |
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| BDBM50330702 | |||
| n/a | |||
| Name | BDBM50330702 | ||
| Synonyms: | 1-acetyl-4-methyl-5-(pyridin-3-ylmethyl)-2-o-tolyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | CHEMBL1277766 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H20N4O3 | ||
| Mol. Mass. | 388.4192 | ||
| SMILES | CC(=O)n1n(-c2ccccc2C)c(=O)c2c(C)n(Cc3cccnc3)c(=O)cc12 |(31.69,-42.59,;30.93,-41.25,;29.39,-41.24,;31.71,-39.93,;30.81,-38.68,;29.27,-38.68,;28.51,-40.01,;26.97,-40.01,;26.19,-38.67,;26.97,-37.34,;28.51,-37.34,;29.28,-36.01,;31.72,-37.43,;31.24,-35.97,;33.18,-37.91,;34.51,-37.14,;34.5,-35.6,;35.85,-37.9,;37.18,-37.12,;38.52,-37.89,;38.52,-39.43,;39.85,-40.19,;41.18,-39.42,;41.17,-37.87,;39.84,-37.11,;35.85,-39.45,;37.19,-40.22,;34.51,-40.22,;33.18,-39.45,)| | ||
| Structure | 
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