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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | NADPH oxidase 4 | ||
| Ligand | BDBM50330703 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685143 (CHEMBL1286959) | ||
| Ki | 240±n/a nM | ||
| Citation |  Laleu, B; Gaggini, F; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem53:7715-30 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| NADPH oxidase 4 | |||
| Name: | NADPH oxidase 4 | ||
| Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 66954.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_792879 | ||
| Residue: | 578 | ||
| Sequence: |
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| BDBM50330703 | |||
| n/a | |||
| Name | BDBM50330703 | ||
| Synonyms: | 1-acetyl-2-(2-chlorophenyl)-4-methyl-5-(pyridin-3-ylmethyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | CHEMBL1277850 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H17ClN4O3 | ||
| Mol. Mass. | 408.838 | ||
| SMILES | CC(=O)n1n(-c2ccccc2Cl)c(=O)c2c(C)n(Cc3cccnc3)c(=O)cc12 |(50.73,-44.13,;49.97,-42.79,;48.42,-42.78,;50.74,-41.46,;49.84,-40.21,;48.3,-40.21,;47.54,-41.54,;46,-41.55,;45.22,-40.21,;46,-38.87,;47.54,-38.88,;48.31,-37.54,;50.75,-38.97,;50.27,-37.5,;52.21,-39.45,;53.54,-38.67,;53.53,-37.13,;54.88,-39.43,;56.21,-38.66,;57.55,-39.42,;57.55,-40.96,;58.88,-41.73,;60.22,-40.95,;60.21,-39.4,;58.87,-38.64,;54.88,-40.99,;56.22,-41.75,;53.55,-41.76,;52.21,-40.99,)| | ||
| Structure | 
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