| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage metalloelastase |
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| Ligand | BDBM50333941 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_700258 (CHEMBL1647476) |
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| IC50 | 24±n/a nM |
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| Citation |  Badland, M; Compère, D; Courté, K; Dublanchet, AC; Blais, S; Manage, A; Peron, G; Wrigglesworth, R Thiophene and bioisostere derivatives as new MMP12 inhibitors. Bioorg Med Chem Lett21:528-30 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage metalloelastase |
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| Name: | Macrophage metalloelastase |
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| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54012.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P39900 |
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| Residue: | 470 |
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| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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| BDBM50333941 |
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| n/a |
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| Name | BDBM50333941 |
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| Synonyms: | (R)-3-(4-(4'-acetylbiphenyl-4-yl)-5-fluorothiophene-2-carboxamido)-3-phenylpropanoic acid | CHEMBL1644430 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H22FNO4S |
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| Mol. Mass. | 487.542 |
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| SMILES | CC(=O)c1ccc(cc1)-c1ccc(cc1)-c1cc(sc1F)C(=O)N[C@H](CC(O)=O)c1ccccc1 |r| |
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| Structure | 
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