| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
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| Ligand | BDBM50335373 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_701594 (CHEMBL1656353) |
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| IC50 | >1000±n/a nM |
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| Citation |  Hille, UE; Zimmer, C; Vock, CA; Hartmann, RW First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases ACS Med Chem Lett2:2-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B2, mitochondrial |
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| Name: | Cytochrome P450 11B2, mitochondrial |
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| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
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| Type: | Protein |
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| Mol. Mass.: | 57582.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P19099 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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| BDBM50335373 |
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| n/a |
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| Name | BDBM50335373 |
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| Synonyms: | 1-(3,3,3-Triphenyl-propyl)-1H-benzoimidazole | CHEMBL1651512 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H24N2 |
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| Mol. Mass. | 388.5036 |
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| SMILES | C(CC(c1ccccc1)(c1ccccc1)c1ccccc1)n1cnc2ccccc12 |
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| Structure | 
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