Reaction Details |
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Target | DNA polymerase alpha catalytic subunit |
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Ligand | BDBM50336502 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_720296 (CHEMBL1679162) |
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IC50 | >100000±n/a nM |
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Citation | Nyanguile, O; Pauwels, F; Van den Broeck, W; Boutton, CW; Quirynen, L; Ivens, T; van der Helm, L; Vandercruyssen, G; Mostmans, W; Delouvroy, F; Dehertogh, P; Cummings, MD; Bonfanti, JF; Simmen, KA; Raboisson, P 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors. Antimicrob Agents Chemother52:4420-31 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA polymerase alpha catalytic subunit |
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Name: | DNA polymerase alpha catalytic subunit |
Synonyms: | DNA polymerase (alpha/delta/epsilon) | DNA polymerase alpha subunit | DPOLA_HUMAN | POLA | POLA1 |
Type: | PROTEIN |
Mol. Mass.: | 165895.25 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1365493 |
Residue: | 1462 |
Sequence: | MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEE
VDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDK
RNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMI
LKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEE
EQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSF
LPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVF
LFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEK
IATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTN
TSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVM
AFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKE
VIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWS
KIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTER
VVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTL
MGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYA
GGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPE
LPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCL
GFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFK
LGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIV
RRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALT
KDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQK
QDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDAL
LGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPL
TFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQ
PEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQF
LSRSGYSEVNLSKLFAGCAVKS
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BDBM50336502 |
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n/a |
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Name | BDBM50336502 |
Synonyms: | 10-acetyl-11-(2,4-dichlorophenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one | CHEMBL467903 |
Type | Small organic molecule |
Emp. Form. | C23H22Cl2N2O2 |
Mol. Mass. | 429.339 |
SMILES | CC(=O)N1C(C2C(=O)CC(C)(C)CC2=Nc2ccccc12)c1ccc(Cl)cc1Cl |c:14| |
Structure |
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