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TargetDNA polymerase beta
LigandBDBM50336502
Substrate/Competitorn/a
Meas. Tech.ChEMBL_720297 (CHEMBL1679163)
IC50>100000±n/a nM
Citation Nyanguile, OPauwels, FVan den Broeck, WBoutton, CWQuirynen, LIvens, Tvan der Helm, LVandercruyssen, GMostmans, WDelouvroy, FDehertogh, PCummings, MDBonfanti, JFSimmen, KARaboisson, P 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors. Antimicrob Agents Chemother52:4420-31 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA polymerase beta
Name:DNA polymerase beta
Synonyms:DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:Protein
Mol. Mass.:38188.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50336502
n/a
NameBDBM50336502
Synonyms:10-acetyl-11-(2,4-dichlorophenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one | CHEMBL467903
TypeSmall organic molecule
Emp. Form.C23H22Cl2N2O2
Mol. Mass.429.339
SMILESCC(=O)N1C(C2C(=O)CC(C)(C)CC2=Nc2ccccc12)c1ccc(Cl)cc1Cl |c:14|
Structure
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