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TargetProtein Mdm4
LigandBDBM50339170
Substrate/Competitorn/a
Meas. Tech.ChEMBL_735890 (CHEMBL1694394)
IC50 410±n/a nM
Citation Madden, MMMuppidi, ALi, ZLi, XChen, JLin, Q Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition. Bioorg Med Chem Lett21:1472-5 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein Mdm4
Name:Protein Mdm4
Synonyms:Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:Oncoprotein
Mol. Mass.:54842.04
Organism:Homo sapiens (Human)
Description:The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50339170
n/a
NameBDBM50339170
Synonyms:CHEMBL1689402
TypeSmall organic molecule
Emp. Form.C92H133N27O20
Mol. Mass.1937.2093
SMILESCOc1ccc(cc1)-n1nnc(n1)C(=O)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCNC(=O)C(C)=C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CO)C(N)=O |r,wU:52.66,32.39,20.22,118.128,103.116,78.90,wD:41.50,24.30,133.138,114.120,127.134,89.104,66.79,(48.94,2.99,;47.41,3.14,;46.51,1.9,;47.14,.51,;46.24,-.74,;44.71,-.58,;44.08,.81,;44.97,2.06,;43.81,-1.83,;42.27,-1.83,;41.8,-3.28,;43.05,-4.19,;44.29,-3.3,;43.05,-5.73,;44.38,-6.5,;41.72,-6.5,;41.72,-8.04,;40.39,-8.81,;40.39,-10.35,;39.06,-11.12,;39.06,-12.66,;37.72,-13.43,;36.39,-12.66,;36.39,-11.11,;35.06,-13.43,;35.06,-14.97,;36.39,-15.74,;36.39,-17.28,;37.73,-14.97,;33.72,-12.67,;32.38,-13.44,;32.38,-14.98,;31.05,-12.66,;31.05,-11.12,;32.38,-10.35,;32.38,-8.8,;31.04,-8.03,;33.72,-8.04,;29.71,-13.44,;28.38,-12.67,;28.38,-11.13,;27.04,-13.44,;27.04,-14.98,;28.37,-15.75,;28.37,-17.29,;29.7,-18.05,;29.7,-19.59,;31.03,-20.36,;28.37,-20.36,;25.71,-12.67,;24.37,-13.44,;24.37,-14.98,;23.03,-12.68,;23.03,-11.13,;24.37,-10.36,;25.77,-10.98,;26.81,-9.83,;26.03,-8.5,;26.51,-7.02,;25.47,-5.89,;23.97,-6.22,;23.49,-7.68,;24.52,-8.82,;21.69,-13.45,;20.37,-12.68,;20.37,-11.13,;19.03,-13.45,;19.03,-14.99,;20.37,-15.77,;21.7,-14.99,;23.04,-15.76,;23.04,-17.3,;24.37,-18.07,;21.71,-18.07,;20.37,-17.31,;17.69,-12.68,;16.36,-13.45,;16.36,-14.99,;15.02,-12.69,;15.02,-11.14,;16.35,-10.37,;16.35,-8.84,;17.68,-8.07,;17.68,-6.53,;19.02,-5.76,;16.35,-5.76,;13.68,-13.46,;12.35,-12.69,;12.35,-11.14,;11.02,-13.46,;11.02,-15,;9.69,-15.77,;9.69,-17.31,;8.36,-18.08,;8.36,-19.61,;7.03,-20.38,;5.7,-19.62,;7.03,-21.92,;5.7,-22.69,;8.37,-22.69,;9.68,-12.7,;8.34,-13.47,;8.34,-15.01,;7.01,-12.69,;7.01,-11.15,;8.34,-10.38,;9.67,-11.15,;11.01,-10.37,;11.01,-8.83,;9.67,-8.06,;8.33,-8.83,;5.67,-13.47,;4.34,-12.7,;4.34,-11.16,;3,-13.47,;1.67,-12.7,;.32,-13.47,;.32,-15.01,;-1.01,-12.7,;-1.01,-11.16,;.32,-10.39,;.32,-8.84,;1.66,-11.16,;-2.35,-13.47,;-3.68,-12.7,;-5.01,-13.47,;-3.67,-11.16,;3,-15.01,;1.67,-15.78,;4.34,-15.78,;40.4,-13.42,;40.4,-14.96,;41.74,-12.65,;43.07,-13.42,;43.07,-14.96,;44.41,-15.74,;44.41,-12.65,;45.74,-13.42,;44.41,-11.1,)|
Structure
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