| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50340679 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_740136 (CHEMBL1763196) |
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| IC50 | 5400±n/a nM |
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| Citation |  Tzioumaki, N; Manta, S; Tsoukala, E; Vande Voorde, J; Liekens, S; Komiotis, D; Balzarini, J Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase. Eur J Med Chem46:993-1005 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TS | TSase | TYSY_MOUSE | Tyms |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34957.15 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1340097 |
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| Residue: | 307 |
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| Sequence: | MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYS
LRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSAR
QEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKD
LPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPG
DFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPT
IKMEMAV
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| BDBM50340679 |
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| n/a |
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| Name | BDBM50340679 |
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| Synonyms: | CHEMBL1762230 | exo-1-((2S,4S,5R)-4,5-dihydroxy-3-methylenetetrahydro-2H-pyran-2-yl)-5-fluoro-4-hydroxypyrimidin-2(1H)-one |
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| Type | Small organic molecule |
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| Emp. Form. | C10H11FN2O5 |
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| Mol. Mass. | 258.2031 |
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| SMILES | O[C@@H]1CO[C@@H](C(=C)[C@@H]1O)n1cc(F)c(=O)[nH]c1=O |r| |
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| Structure | 
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