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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Nociceptin receptor | ||
| Ligand | BDBM50340707 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_740151 (CHEMBL1763211) | ||
| IC50 | 25.2±n/a nM | ||
| Citation |  Del Giudice, MR; Borioni, A; Bastanzio, G; Sbraccia, M; Mustazza, C; Sestili, I Synthesis and pharmacological evaluation of bivalent antagonists of the nociceptin opioid receptor. Eur J Med Chem46:1207-21 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Nociceptin receptor | |||
| Name: | Nociceptin receptor | ||
| Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 40702.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41146 | ||
| Residue: | 370 | ||
| Sequence: |
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| BDBM50340707 | |||
| n/a | |||
| Name | BDBM50340707 | ||
| Synonyms: | CHEMBL1762371 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C53H82N6O2 | ||
| Mol. Mass. | 835.2572 | ||
| SMILES | CC(C)[C@H]1CC[C@H](CC1)N1CCC2(CC1)N(CN(CCCCCCCCCN1CN(c3ccccc3)C3(CCN(CC3)[C@@H]3CC[C@@H](CC3)C(C)C)C1=O)C2=O)c1ccccc1 |r,wU:42.45,45.52,6.9,3.2,(-6.97,3.8,;-6.2,2.46,;-6.98,1.13,;-4.66,2.46,;-3.89,3.78,;-2.35,3.78,;-1.59,2.44,;-2.37,1.11,;-3.91,1.12,;-.05,2.43,;.71,1.08,;2.24,1.07,;3.03,2.39,;2.27,3.74,;.73,3.75,;3.8,1.06,;5.3,1.37,;5.46,2.9,;6.8,3.67,;8.13,2.89,;9.46,3.66,;10.8,2.88,;12.13,3.65,;13.47,2.88,;14.8,3.66,;16.13,2.89,;17.47,3.67,;18.8,2.9,;18.97,1.37,;20.47,1.06,;21.09,-.34,;22.63,-.5,;23.26,-1.9,;22.36,-3.15,;20.82,-2.99,;20.19,-1.58,;21.23,2.39,;22.02,1.07,;23.55,1.08,;24.31,2.43,;23.54,3.75,;21.99,3.74,;25.85,2.44,;26.63,1.11,;28.17,1.12,;28.93,2.46,;28.15,3.78,;26.61,3.78,;30.47,2.46,;31.23,3.8,;31.24,1.13,;20.2,3.53,;20.52,5.03,;4.06,3.53,;3.75,5.03,;3.17,-.34,;1.64,-.5,;1,-1.9,;1.91,-3.15,;3.45,-2.99,;4.07,-1.58,)| | ||
| Structure | 
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