| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
|---|
| Ligand | BDBM50342894 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_744200 (CHEMBL1771957) |
|---|
| IC50 | 541±n/a nM |
|---|
| Citation |  Rosenthal, AS; Tanega, C; Shen, M; Mott, BT; Bougie, JM; Nguyen, DT; Misteli, T; Auld, DS; Maloney, DJ; Thomas, CJ Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Bioorg Med Chem Lett21:3152-8 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
|---|
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A |
|---|
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 85616.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13627 |
|---|
| Residue: | 763 |
|---|
| Sequence: | MHTGGETSACKPSSVRLAPSFSFHAAGLQMAGQMPHSHQYSDRRQPNISDQQVSALSYSD
QIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQ
QGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRV
EQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEM
LSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKR
SAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPL
FSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGT
RKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK
KTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGG
HFTAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHH
HHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSS
STTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTY
QFSANTGPAHYMTEGHLTMRQGADREESPMTGVCVQQSPVASS
|
|
|
|---|
| BDBM50342894 |
|---|
| n/a |
|---|
| Name | BDBM50342894 |
|---|
| Synonyms: | CHEMBL1515868 | N-(2-(1H-imidazol-4-yl)ethyl)-6-(benzo[d][1,3]dioxol-5-yl)quinazolin-4-amine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17N5O2 |
|---|
| Mol. Mass. | 359.3813 |
|---|
| SMILES | C(Cc1cnc[nH]1)Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
