Reaction Details |
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Target | Sphingosine kinase 1 |
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Ligand | BDBM50343820 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_747639 (CHEMBL1777257) |
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Ki | 1500±n/a nM |
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Citation | Kennedy, AJ; Mathews, TP; Kharel, Y; Field, SD; Moyer, ML; East, JE; Houck, JD; Lynch, KR; Macdonald, TL Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. J Med Chem54:3524-48 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine kinase 1 |
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Name: | Sphingosine kinase 1 |
Synonyms: | SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1) |
Type: | Enzyme |
Mol. Mass.: | 42521.16 |
Organism: | Homo sapiens (Human) |
Description: | Q9NYA1 |
Residue: | 384 |
Sequence: | MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
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BDBM50343820 |
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n/a |
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Name | BDBM50343820 |
Synonyms: | CHEMBL1774562 | N-(4-(7-((Adamantan-1-ylmethoxy)heptyl)phenyl)-1-carbamimidoylcyclopropanecarboxamide Hydrochloride |
Type | Small organic molecule |
Emp. Form. | C29H43N3O2 |
Mol. Mass. | 465.6706 |
SMILES | NC(=N)C1(CC1)C(=O)Nc1ccc(CCCCCCCOCC23CC4CC(CC(C4)C2)C3)cc1 |TLB:21:22:25:29.28.27,THB:23:24:27:31.22.30,23:22:25.24.29:27,30:22:25:29.28.27,30:28:25:31.23.22| |
Structure |
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