| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine kinase 2 |
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| Ligand | BDBM50343818 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_747638 (CHEMBL1777256) |
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| Ki | 7000±n/a nM |
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| Citation |  Kennedy, AJ; Mathews, TP; Kharel, Y; Field, SD; Moyer, ML; East, JE; Houck, JD; Lynch, KR; Macdonald, TL Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. J Med Chem54:3524-48 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine kinase 2 |
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| Name: | Sphingosine kinase 2 |
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| Synonyms: | SK 2 | SPHK2_MOUSE | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase 2 (SPHK2) | Sphk2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 65617.92 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q9JIA7 |
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| Residue: | 617 |
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| Sequence: | MAPPPLLPVAASTPILHGEFGSYPANGPRFALTLTTQALHIQRLRPKPEARPRDGLVSLD
EVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRADGATTYEENRAEAQRWAT
ALTCLLRGVPLSGDQEITPELLPRKPRLLILVNPFGGRGLAWQRCMDHVVPMISEAGLSF
NLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEVLNGLLDRPDWEDAVRMPIGVLP
CGSGNALAGAVNHHGGFEQVVGVDLLLNCSLLLCRGGSHPLDLLSVTLASGSRCFSFLSV
AWGFLSDVDIHSERFRALGSARFTLGAVLGLASLHTYRGRLSYLPATTEPALPIPGHSLP
RAKSELVLAPAPAPAATHSPLHRSVSDLPLPLPQPALVSPGSPEPLPDLSLNGGGPELTG
DWGGAGDAPLSPDPLLPSSPNALKTAQLSPIAEGPPEMPASSGFLPPTHSAPEASTWGPV
DHLLPPLGSPLPQDWVTIEGEFVLMLGILPSHLCADLMAAPHARFDDGVVHLCWVRSGIS
RAALLRILLAMEHGNHFSLGCPHLGYAAARAFRLEPLTPRGLLTVDGELVEYGPIQAQVH
PGLATLLTGPAGQKPQA
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| BDBM50343818 |
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| n/a |
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| Name | BDBM50343818 |
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| Synonyms: | 1-Carbamimidoyl-N-(4-(7-(cyclohexylmethoxy)heptyl)phenyl)cyclopropanecarboxamide Hydrochloride | CHEMBL1774560 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H39N3O2 |
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| Mol. Mass. | 413.5961 |
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| SMILES | NC(=N)C1(CC1)C(=O)Nc1ccc(CCCCCCCOCC2CCCCC2)cc1 |
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| Structure | 
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