Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | D(4) dopamine receptor | ||
Ligand | BDBM50343894 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_747461 (CHEMBL1776961) | ||
Ki | 890±n/a nM | ||
Citation | Al Hussainy, R; Verbeek, J; van der Born, D; Braker, AH; Leysen, JE; Knol, RJ; Booij, J; Herscheid, JK Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor. J Med Chem54:3480-91 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
D(4) dopamine receptor | |||
Name: | D(4) dopamine receptor | ||
Synonyms: | D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor | ||
Type: | Enzyme | ||
Mol. Mass.: | 48373.19 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P21917 | ||
Residue: | 419 | ||
Sequence: |
| ||
BDBM50343894 | |||
n/a | |||
Name | BDBM50343894 | ||
Synonyms: | CHEMBL1774995 | N-(2-(4-(2-Hydroxyphenyl)piperazin-1-yl)ethyl)-4-iodo-N-(pyridin-2-yl)cubyl-1-carboxamide | ||
Type | Small organic molecule | ||
Emp. Form. | C26H27IN4O2 | ||
Mol. Mass. | 554.4227 | ||
SMILES | Oc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 |(16.06,-35.05,;15.3,-36.38,;13.75,-36.39,;12.99,-37.73,;13.77,-39.05,;15.31,-39.05,;16.08,-37.72,;17.61,-37.71,;18.38,-39.05,;19.91,-39.05,;20.69,-37.72,;22.22,-37.72,;22.99,-36.39,;24.53,-36.39,;25.3,-35.06,;26.84,-35.06,;24.54,-33.72,;22.6,-33.6,;22.86,-31.67,;24.8,-31.78,;24.28,-31.26,;24.04,-33.21,;22.1,-33.08,;22.36,-31.14,;21.37,-29.96,;25.3,-37.72,;26.83,-37.71,;27.6,-39.06,;26.82,-40.39,;25.28,-40.38,;24.52,-39.05,;19.91,-36.38,;18.37,-36.38,)| | ||
Structure |