Ki Summary

Reaction Details

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Target

Motilin receptor

Ligand

BDBM50344947

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_748951 (CHEMBL1781399)

EC50

140±n/a nM

Citation

Liu, Y; Carreras, CW; Claypool, M; Myles, DC; Shaw, SJ The role of the 4''-hydroxyl on motilin agonist potency in the 9-dihydroerythromycin series. Bioorg Med Chem Lett21:3712-4 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Motilin receptor

Name:

Motilin receptor

Synonyms:

n/a

Type:

n/a

Mol. Mass.:

43771.25

Organism:

Oryctolagus cuniculus

Description:

n/a

Residue:

400

Sequence:

MGSPWNGSDGPEDAREPPWAALPPCDERRCSPFPLGTLVPVTAVCLGLFAVGVSGNVVTV
LLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGQLLCRLSLYVGEG
CTYASLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAALWAVALLSAGPFFFLVGVE
QDPAVFAAPDRNGTVPLDPSSPAPASPPSGPGAEAAALFSRECRPSRAQLGLLRVMLWVT
TAYFFLPFLCLSILYGLIARQLWRGRGPLRGPAATGRERGHRQTVRVLLVVVLAFIVCWL
PFHVGRIIYINTQDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAARRLLRE
SRAGPSGVCGSRGPEQDVAGDTGGDTAGCTETSANTKTAA

BDBM50344947

n/a

Name

BDBM50344947

Synonyms:

(3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-14-ethyl-7,10,12,13-tetrahydroxy-6-((2S,3R,4S,6R)-3-hydroxy-4-(((S)-2-hydroxypropyl)(methyl)amino)-6-methyltetrahydro-2H-pyran-2-yloxy)-4-((2S,4S,6S)-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yloxy)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one | CHEMBL1778049

Type

Small organic molecule

Emp. Form.

C39H73NO13

Mol. Mass.

763.9958

SMILES

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@](C)(C[C@H](C)O2)OC)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C[C@H](C)O)[C@](C)(O)C[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@]1(C)O |r|

Structure