| Reaction Details |
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 | Report a problem with these data |
| Target | Extracellular calcium-sensing receptor |
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| Ligand | BDBM50346036 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_750426 (CHEMBL1785978) |
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| IC50 | 320±n/a nM |
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| Citation |  Balan, G; Bauman, J; Bhattacharya, S; Castrodad, M; Healy, DR; Herr, M; Humphries, P; Jennings, S; Kalgutkar, AS; Kapinos, B; Khot, V; Lazarra, K; Li, M; Li, Y; Neagu, C; Oliver, R; Piotrowski, DW; Price, D; Qi, H; Simmons, HA; Southers, J; Wei, L; Zhang, Y; Paralkar, VM The discovery of novel calcium sensing receptor negative allosteric modulators. Bioorg Med Chem Lett19:3328-32 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Extracellular calcium-sensing receptor |
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| Name: | Extracellular calcium-sensing receptor |
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| Synonyms: | CASR_RAT | Calcium sensing receptor | Casr | Gprc2a | Parathyroid Cell calcium-sensing receptor | Pcar1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 120858.46 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_750426 |
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| Residue: | 1079 |
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| Sequence: | MASYSCCLALLALAWHSSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
IRYNFRGFRWLQAMIFAIEEINSSPSLLPNMTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQY
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
ELISQYSDEEEIQQVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGRIWLASEAWA
SSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNGFAKEFWEETFNCHL
QEGAKGPLPVDTFVRSHEEGGNRLLNSSTAFRPLCTGDENINSVETPYMDYEHLRISYNV
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
NCSRDCQAGTRKGIIEGEPTCCFECVECPDGEYSGETDASACDKCPDDFWSNENHTSCIA
KEIEFLAWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
LNLQFLLVFLCTFMQILICIIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGSLIGYT
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKVYIILFKPSRNTIEEVRSSTAAHAFKVAARATLRRPNISRKRSS
SLGGSTGSIPSSSISSKSNSEDRFPQPERQKQQQPLSLTQQEQQQQPLTLHPQQQQQPQQ
PRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSMRQNSLEAQRSNDTLGRHQALLPLQCA
DADSEMTIQETGLQGPMVGDHQPEMESSDEMSPALVMSTSRSFVISGGGSSVTENVLHS
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| BDBM50346036 |
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| n/a |
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| Name | BDBM50346036 |
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| Synonyms: | CHEMBL1198855 | Ronacaleret |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31F2NO4 |
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| Mol. Mass. | 447.5147 |
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| SMILES | CC(C)(CC1Cc2ccccc2C1)NC[C@@H](O)COc1cc(CCC(O)=O)cc(F)c1F |r| |
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| Structure | 
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