| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage metalloelastase |
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| Ligand | BDBM50346324 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_750611 (CHEMBL1785457) |
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| IC50 | 70±n/a nM |
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| Citation |  Ishikawa, M; Hashimoto, Y Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry. J Med Chem54:1539-54 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage metalloelastase |
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| Name: | Macrophage metalloelastase |
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| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54012.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P39900 |
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| Residue: | 470 |
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| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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| BDBM50346324 |
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| n/a |
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| Name | BDBM50346324 |
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| Synonyms: | 2-(4-((4-(biphenyl-4-yl)thiophene-2-carboxamido)methyl)phenyl)acetic acid | CHEMBL1782664 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H21NO3S |
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| Mol. Mass. | 427.515 |
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| SMILES | OC(=O)Cc1ccc(CNC(=O)c2cc(cs2)-c2ccc(cc2)-c2ccccc2)cc1 |
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| Structure | 
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