Reaction Details |
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Target | Macrophage metalloelastase |
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Ligand | BDBM50346325 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_750611 (CHEMBL1785457) |
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IC50 | 90±n/a nM |
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Citation | Ishikawa, M; Hashimoto, Y Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry. J Med Chem54:1539-54 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Macrophage metalloelastase |
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Name: | Macrophage metalloelastase |
Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
Type: | Enzyme |
Mol. Mass.: | 54012.99 |
Organism: | Homo sapiens (Human) |
Description: | P39900 |
Residue: | 470 |
Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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BDBM50346325 |
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n/a |
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Name | BDBM50346325 |
Synonyms: | 2-(4-((4-(2'-hydroxybiphenyl-4-yl)thiophene-2-carboxamido)methyl)phenyl)acetic acid | CHEMBL1782665 |
Type | Small organic molecule |
Emp. Form. | C26H21NO4S |
Mol. Mass. | 443.514 |
SMILES | OC(=O)Cc1ccc(CNC(=O)c2cc(cs2)-c2ccc(cc2)-c2ccccc2O)cc1 |
Structure |
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