Reaction Details |
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Target | Voltage-dependent calcium channel subunit alpha-2/delta-2 |
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Ligand | BDBM50348473 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_754900 (CHEMBL1805884) |
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IC50 | 794±n/a nM |
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Citation | Myatt, JW; Healy, MP; Bravi, GS; Billinton, A; Johnson, CN; Matthews, KL; Jandu, KS; Meng, W; Hersey, A; Livermore, DG; Douault, CB; Witherington, J; Bit, RA; Rowedder, JE; Brown, JD; Clayton, NM Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain. Bioorg Med Chem Lett20:4683-8 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Voltage-dependent calcium channel subunit alpha-2/delta-2 |
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Name: | Voltage-dependent calcium channel subunit alpha-2/delta-2 |
Synonyms: | CA2D2_HUMAN | CACNA2D2 | KIAA0558 | Voltage-gated calcium channel | Voltage-gated calcium channel alpha2/delta subunit 2 |
Type: | PROTEIN |
Mol. Mass.: | 129803.50 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_754900 |
Residue: | 1150 |
Sequence: | MAVPARTCGASRPGPARTARPWPGCGPHPGPGTRRPTSGPPRPLWLLLPLLPLLAAPGAS
AYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVA
GDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVER
GSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRR
QDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSG
SVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQANVRNKKVFKEAV
QGMVAKGTTGYKAGFEYAFDQLQNSNITRANCNKMIMMFTDGGEDRVQDVFEKYNWPNRT
VRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEA
KQVQWTNVYEDALGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPN
YTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMIDGN
KGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFYLQANLSDQILQV
KLPISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDNNTEFLKNFIELMEKVTPDSK
QCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTE
NPEPFNASFYRRSLDNHGYVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTLRPA
VVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLV
LSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVF
VPTVADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQY
YFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHSDGP
EQCELVQRPRYRRGPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQP
QVLVHASRRL
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BDBM50348473 |
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n/a |
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Name | BDBM50348473 |
Synonyms: | CHEMBL1801185 |
Type | Small organic molecule |
Emp. Form. | C18H17ClF3N5O |
Mol. Mass. | 411.809 |
SMILES | Cc1n(nc2c(nnc(C)c12)N1CCCC1)-c1ccc(Cl)cc1OC(F)(F)F |
Structure |
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