| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50350124 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_760996 (CHEMBL1815024) |
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| Ki | 8000±n/a nM |
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| Citation |  Mangani, S; Cancian, L; Leone, R; Pozzi, C; Lazzari, S; Luciani, R; Ferrari, S; Costi, MP Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening. J Med Chem54:5454-67 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TS | TSase | TYSY_ENTFA | thyA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36331.56 |
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| Organism: | Enterococcus faecalis |
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| Description: | ChEMBL_760996 |
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| Residue: | 315 |
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| Sequence: | MEEAYLALGKKILEEGHFKEDRTGTGTYSLFGYQMRFDLAKGFPLLTTKRVPFGLIKSEL
LWFLKGDTNIRYLLERNNHIWDEWAFERYVKSADYQGPDMTDFGHRVLQDPAFAEQYKEE
HQKFCDAILNDAEFAEKYGELGNIYGAQWRHWETKDGSFIDQLANVIEMIKTNPDSRRLI
VSAWNPEDVPSMALPPCHTMFQFYVNEGKLSCQLYQRSADVFLGVPFNIASYALLTHLIA
HETGLEVGEFVHTLGDAHLYQNHVEQMQEQLSREVRSFPTLVLNPDKASVFDFDMEDIKV
EGYDPHPTIKAPIAV
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| BDBM50350124 |
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| n/a |
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| Name | BDBM50350124 |
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| Synonyms: | CHEMBL1231557 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10N2O2 |
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| Mol. Mass. | 262.2628 |
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| SMILES | Cc1cccc2C(=O)N(C(=O)c12)c1ccc(cc1)C#N |
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| Structure | 
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