| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Liver carboxylesterase 1 |
|---|
| Ligand | BDBM22850 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_762143 (CHEMBL1816214) |
|---|
| Ki | 27±n/a nM |
|---|
| Citation |  Parkinson, EI; Jason Hatfield, M; Tsurkan, L; Hyatt, JL; Edwards, CC; Hicks, LD; Yan, B; Potter, PM Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones. Bioorg Med Chem19:4635-43 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Liver carboxylesterase 1 |
|---|
| Name: | Liver carboxylesterase 1 |
|---|
| Synonyms: | Carboxylesterase 1 | EST1_RABIT | liver carboxylesterase 1 | rCE |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 62292 |
|---|
| Organism: | Oryctolagus cuniculus (rabbit) |
|---|
| Description: | n/a |
|---|
| Residue: | 565 |
|---|
| Sequence: | MWLCALALASLAACTAWGHPSAPPVVDTVHGKVLGKFVSLEGFAQPVAVFLGVPFAKPPL
GSLRFAPPQPAESWSHVKNTTSYPPMCSQDAVSGHMLSELFTNRKENIPLKFSEDCLYLN
IYTPADLTKRGRLPVMVWIHGGGLMVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIANFGGDPGSVTIFGESAGGQSVSILLLSPLTKNLF
HRAISESGVALLSSLFRKNTKSLAEKIAIEAGCKTTTSAVMVHCLRQKTEEELMEVTLKM
KFMALDLVGDPKENTAFLTTVIDGVLLPKAPAEILAEKKYNMLPYMVGINQQEFGWIIPM
QMLGYPLSEGKLDQKTATELLWKSYPIVNVSKELTPVATEKYLGGTDDPVKKKDLFLDML
ADLLFGVPSVNVARHHRDAGAPTYMYEYRYRPSFSSDMRPKTVIGDHGDEIFSVLGAPFL
KEGATEEEIKLSKMVMKYWANFARNGNPNGEGLPQWPAYDYKEGYLQIGATTQAAQKLKD
KEVAFWTELWAKEAARPRETEHIEL
|
|
|
|---|
| BDBM22850 |
|---|
| n/a |
|---|
| Name | BDBM22850 |
|---|
| Synonyms: | 1,2-Dione-Based Compound, 7 | 1,2-dicyclohexylethane-1,2-dione |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H22O2 |
|---|
| Mol. Mass. | 222.3233 |
|---|
| SMILES | O=C(C1CCCCC1)C(=O)C1CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
