Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359098 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 11600±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
| ||
| BDBM50359098 | |||
| n/a | |||
| Name | BDBM50359098 | ||
| Synonyms: | CHEMBL1922817 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H38N4O4S | ||
| Mol. Mass. | 562.723 | ||
| SMILES | CS(=O)(=O)c1ccc(\C=C\C(=O)N2CCC(CC2)C(NC2CCC(CC2)c2c[nH]c3ccccc23)C(N)=O)cc1 |(24.34,-27.55,;23.01,-26.77,;22.23,-25.43,;23.4,-25.28,;21.67,-27.54,;21.66,-29.08,;20.33,-29.84,;19,-29.06,;17.66,-29.82,;16.34,-29.04,;15,-29.8,;14.99,-31.34,;13.67,-29.02,;12.33,-29.78,;11,-29.01,;11.02,-27.46,;12.34,-26.7,;13.68,-27.48,;9.69,-26.69,;8.35,-27.46,;8.35,-29,;7.01,-29.76,;7.01,-31.29,;8.34,-32.07,;9.67,-31.3,;9.68,-29.76,;8.33,-33.61,;7.09,-34.52,;7.57,-35.98,;9.1,-35.97,;10.13,-37.11,;11.64,-36.79,;12.11,-35.32,;11.08,-34.19,;9.58,-34.51,;9.69,-25.15,;8.36,-24.38,;11.03,-24.38,;19,-27.52,;20.34,-26.76,)| | ||
| Structure | 
| ||