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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359099 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 130±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
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| BDBM50359099 | |||
| n/a | |||
| Name | BDBM50359099 | ||
| Synonyms: | CHEMBL1922816 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H35ClN4O2 | ||
| Mol. Mass. | 519.078 | ||
| SMILES | NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1ccc(Cl)cc1 |(-8.82,-24.84,;-7.49,-25.62,;-6.15,-24.85,;-7.49,-27.16,;-8.83,-27.92,;-8.83,-29.46,;-10.17,-30.22,;-10.17,-31.76,;-8.84,-32.53,;-7.51,-31.77,;-7.5,-30.22,;-8.85,-34.07,;-10.09,-34.98,;-9.61,-36.45,;-8.08,-36.44,;-7.05,-37.58,;-5.54,-37.26,;-5.07,-35.79,;-6.1,-34.65,;-7.6,-34.98,;-6.16,-27.93,;-6.18,-29.47,;-4.85,-30.25,;-3.51,-29.49,;-3.5,-27.94,;-4.84,-27.16,;-2.18,-30.26,;-2.19,-31.8,;-.85,-29.5,;.48,-30.28,;1.82,-29.52,;3.14,-30.31,;4.48,-29.55,;4.49,-28,;5.83,-27.24,;3.16,-27.23,;1.82,-27.99,)| | ||
| Structure | 
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