Ki Summary

Reaction Details

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Target

C-C chemokine receptor type 2

Ligand

BDBM50359104

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_789638 (CHEMBL1924723)

IC50

>25000±n/a nM

Citation

Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor type 2

Name:

C-C chemokine receptor type 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

41932.32

Organism:

Homo sapiens (Human)

Description:

P41597

Residue:

374

Sequence:

MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA

BDBM50359104

n/a

Name

BDBM50359104

Synonyms:

CHEMBL1922810

Type

Small organic molecule

Emp. Form.

C28H34N4O2

Mol. Mass.

458.5952

SMILES

NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)c1ccccc1 |(58.09,5.58,;59.42,4.81,;60.76,5.58,;59.42,3.27,;58.08,2.5,;58.08,.96,;56.74,.2,;56.74,-1.33,;58.07,-2.11,;59.41,-1.34,;59.41,.2,;58.06,-3.65,;56.82,-4.56,;57.3,-6.02,;58.84,-6.01,;59.86,-7.15,;61.37,-6.83,;61.84,-5.36,;60.81,-4.23,;59.31,-4.55,;60.75,2.5,;60.74,.95,;62.06,.18,;63.4,.94,;63.41,2.48,;62.08,3.26,;64.73,.16,;64.72,-1.38,;66.07,.92,;67.39,.14,;68.73,.9,;68.74,2.44,;67.4,3.22,;66.07,2.45,)|

Structure