| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
|---|
| Ligand | BDBM50359110 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) |
|---|
| IC50 | 1300±n/a nM |
|---|
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 2 |
|---|
| Name: | C-C chemokine receptor type 2 |
|---|
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41932.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41597 |
|---|
| Residue: | 374 |
|---|
| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
|
|
|
|---|
| BDBM50359110 |
|---|
| n/a |
|---|
| Name | BDBM50359110 |
|---|
| Synonyms: | CHEMBL1922805 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H30F3N3O2 |
|---|
| Mol. Mass. | 485.5412 |
|---|
| SMILES | NC(=O)C(NC1CCC(C1)c1ccccc1)C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
