Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359116 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 15800±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
| ||
| BDBM50359116 | |||
| n/a | |||
| Name | BDBM50359116 | ||
| Synonyms: | CHEMBL1922800 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H34F3N3O2 | ||
| Mol. Mass. | 465.5516 | ||
| SMILES | CC(C)C1CCC(CC1)NC(C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1)C(N)=O |(52.35,-20.41,;51.02,-19.63,;49.68,-20.4,;51.03,-18.1,;49.7,-17.32,;49.7,-15.79,;51.04,-15.03,;52.37,-15.79,;52.37,-17.33,;51.04,-13.49,;52.38,-12.72,;53.71,-13.49,;53.7,-15.04,;55.02,-15.81,;56.36,-15.05,;56.37,-13.51,;55.04,-12.73,;57.69,-15.83,;57.68,-17.37,;59.03,-15.07,;60.36,-15.85,;61.7,-15.09,;61.7,-13.55,;63.03,-12.79,;63.03,-11.25,;64.37,-13.57,;65.7,-12.81,;64.36,-15.11,;65.68,-15.89,;63.02,-15.87,;52.38,-11.18,;51.05,-10.41,;53.72,-10.41,)| | ||
| Structure | 
| ||