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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359118 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 6000±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
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| BDBM50359118 | |||
| n/a | |||
| Name | BDBM50359118 | ||
| Synonyms: | CHEMBL1922798 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H32F3N3O2 | ||
| Mol. Mass. | 499.5678 | ||
| SMILES | NC(=O)C(NC1CCC(CC1)c1ccccc1)C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1 |(10.21,-10.17,;11.54,-10.94,;12.88,-10.17,;11.54,-12.48,;10.2,-13.25,;10.2,-14.79,;8.86,-15.55,;8.86,-17.08,;10.19,-17.86,;11.53,-17.09,;11.53,-15.55,;10.18,-19.39,;8.84,-20.16,;8.83,-21.7,;10.17,-22.47,;11.51,-21.7,;11.51,-20.16,;12.87,-13.25,;12.86,-14.8,;14.18,-15.57,;15.52,-14.81,;15.53,-13.27,;14.2,-12.49,;16.85,-15.59,;16.84,-17.13,;18.19,-14.83,;19.52,-15.61,;20.85,-14.85,;20.86,-13.31,;22.19,-12.55,;22.19,-11.01,;23.53,-13.33,;24.86,-12.56,;23.51,-14.87,;24.84,-15.65,;22.18,-15.63,)| | ||
| Structure | 
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