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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359123 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 950±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
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| BDBM50359123 | |||
| n/a | |||
| Name | BDBM50359123 | ||
| Synonyms: | CHEMBL1922793 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H35F3N4O2 | ||
| Mol. Mass. | 540.6197 | ||
| SMILES | NC(=O)C(NC1CCC(CC1)C1CNc2ccccc12)C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1 |(-8.49,5.51,;-7.15,4.74,;-5.82,5.51,;-7.16,3.2,;-8.5,2.43,;-8.5,.89,;-9.84,.13,;-9.84,-1.4,;-8.51,-2.18,;-7.17,-1.41,;-7.17,.13,;-8.51,-3.72,;-9.76,-4.63,;-9.28,-6.09,;-7.74,-6.08,;-6.71,-7.22,;-5.21,-6.9,;-4.74,-5.43,;-5.77,-4.3,;-7.27,-4.62,;-5.83,2.43,;-5.84,.88,;-4.52,.11,;-3.18,.87,;-3.17,2.41,;-4.5,3.19,;-1.85,.09,;-1.86,-1.45,;-.51,.85,;.82,.07,;2.16,.83,;2.16,2.37,;3.49,3.13,;3.49,4.67,;4.83,2.35,;6.17,3.12,;4.82,.81,;6.14,.03,;3.48,.05,)| | ||
| Structure | 
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