Reaction Details | |||
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Target | C-C chemokine receptor type 2 | ||
Ligand | BDBM50359124 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
IC50 | 670±n/a nM | ||
Citation | Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
C-C chemokine receptor type 2 | |||
Name: | C-C chemokine receptor type 2 | ||
Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
Type: | Enzyme | ||
Mol. Mass.: | 41932.32 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P41597 | ||
Residue: | 374 | ||
Sequence: |
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BDBM50359124 | |||
n/a | |||
Name | BDBM50359124 | ||
Synonyms: | CHEMBL1922792 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H33F3N4O3 | ||
Mol. Mass. | 554.6032 | ||
SMILES | ONC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1 |(38.98,-38.1,;40.32,-37.33,;41.65,-38.11,;42.99,-37.34,;41.65,-39.65,;40.31,-40.41,;40.31,-41.95,;38.97,-42.72,;38.97,-44.25,;40.3,-45.03,;41.63,-44.26,;41.64,-42.71,;40.29,-46.57,;39.05,-47.48,;39.53,-48.94,;41.06,-48.93,;42.09,-50.07,;43.6,-49.75,;44.07,-48.28,;43.04,-47.14,;41.54,-47.47,;42.98,-40.42,;42.96,-41.96,;44.29,-42.74,;45.63,-41.98,;45.64,-40.44,;44.3,-39.65,;46.96,-42.76,;46.95,-44.3,;48.29,-41.99,;49.62,-42.77,;50.96,-42.01,;50.96,-40.48,;52.3,-39.72,;52.3,-38.18,;53.63,-40.5,;54.97,-39.73,;53.62,-42.04,;54.95,-42.82,;52.28,-42.8,)| | ||
Structure |