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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359126 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 980±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
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| BDBM50359126 | |||
| n/a | |||
| Name | BDBM50359126 | ||
| Synonyms: | CHEMBL1922790 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H35F3N4O2 | ||
| Mol. Mass. | 552.6304 | ||
| SMILES | CNC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1 |(-8.01,-39.15,;-6.67,-38.38,;-5.34,-39.16,;-4.01,-38.39,;-5.35,-40.7,;-6.68,-41.46,;-6.68,-43,;-8.02,-43.77,;-8.03,-45.3,;-6.7,-46.08,;-5.36,-45.31,;-5.35,-43.76,;-6.7,-47.62,;-7.95,-48.53,;-7.46,-49.99,;-5.93,-49.98,;-4.9,-51.12,;-3.4,-50.8,;-2.93,-49.33,;-3.96,-48.19,;-5.45,-48.52,;-4.02,-41.47,;-4.03,-43.01,;-2.71,-43.79,;-1.37,-43.03,;-1.36,-41.49,;-2.69,-40.7,;-.04,-43.81,;-.05,-45.35,;1.3,-43.04,;2.63,-43.82,;3.97,-43.06,;3.97,-41.53,;5.3,-40.77,;5.31,-39.23,;6.64,-41.55,;7.98,-40.78,;6.63,-43.09,;7.96,-43.87,;5.29,-43.85,)| | ||
| Structure | 
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