Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359130 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 8600±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
| ||
| BDBM50359130 | |||
| n/a | |||
| Name | BDBM50359130 | ||
| Synonyms: | CHEMBL1922786 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H34F3N3O | ||
| Mol. Mass. | 509.6057 | ||
| SMILES | CC(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1 |(40.78,-8.87,;40.78,-10.41,;39.44,-11.18,;39.44,-12.72,;38.1,-13.48,;38.1,-15.01,;39.43,-15.79,;40.76,-15.02,;40.77,-13.48,;39.42,-17.33,;38.18,-18.24,;38.66,-19.7,;40.19,-19.69,;41.22,-20.83,;42.72,-20.51,;43.2,-19.04,;42.16,-17.91,;40.67,-18.23,;42.11,-11.18,;42.09,-12.73,;43.42,-13.5,;44.76,-12.74,;44.76,-11.2,;43.43,-10.42,;46.09,-13.52,;46.07,-15.06,;47.42,-12.76,;48.75,-13.54,;50.09,-12.78,;50.09,-11.24,;51.42,-10.48,;51.43,-8.94,;52.76,-11.26,;54.1,-10.5,;52.75,-12.8,;54.08,-13.58,;51.41,-13.56,)| | ||
| Structure | 
| ||