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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359132 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 8100±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
| ||
| BDBM50359132 | |||
| n/a | |||
| Name | BDBM50359132 | ||
| Synonyms: | CHEMBL1922784 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H34F3N3O3 | ||
| Mol. Mass. | 553.6152 | ||
| SMILES | CN(C(C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1)C(O)=O)C1CCC(CC1)c1c[nH]c2ccccc12 |(-8.21,-10.82,;-6.88,-11.59,;-5.54,-10.82,;-4.21,-11.6,;-4.22,-13.14,;-2.9,-13.91,;-1.56,-13.15,;-1.55,-11.61,;-2.88,-10.83,;-.23,-13.93,;-.24,-15.47,;1.11,-13.17,;2.44,-13.95,;3.77,-13.19,;3.78,-11.66,;5.11,-10.89,;5.11,-9.35,;6.45,-11.67,;7.78,-10.91,;6.43,-13.21,;7.76,-13.99,;5.1,-13.97,;-5.54,-9.28,;-6.87,-8.51,;-4.2,-8.52,;-6.88,-13.13,;-8.22,-13.89,;-8.22,-15.42,;-6.89,-16.2,;-5.55,-15.43,;-5.55,-13.89,;-6.9,-17.74,;-8.14,-18.65,;-7.66,-20.11,;-6.12,-20.1,;-5.1,-21.24,;-3.59,-20.92,;-3.12,-19.45,;-4.15,-18.32,;-5.65,-18.64,)| | ||
| Structure | 
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