Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359136 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 1890±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
| ||
| BDBM50359136 | |||
| n/a | |||
| Name | BDBM50359136 | ||
| Synonyms: | CHEMBL1922820 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C32H41N5O2 | ||
| Mol. Mass. | 527.7002 | ||
| SMILES | CN(C)c1ccc(\C=C\C(=O)N2CCC(CC2)C(NC2CCC(CC2)c2c[nH]c3ccccc23)C(N)=O)cc1 |(7.79,-42.7,;6.46,-41.93,;6.47,-40.39,;5.12,-42.69,;5.11,-44.23,;3.77,-44.99,;2.45,-44.21,;1.11,-44.97,;-.22,-44.19,;-1.55,-44.95,;-1.56,-46.49,;-2.88,-44.17,;-4.22,-44.93,;-5.55,-44.16,;-5.53,-42.61,;-4.21,-41.85,;-2.87,-42.63,;-6.86,-41.84,;-8.2,-42.61,;-8.2,-44.15,;-9.54,-44.91,;-9.54,-46.44,;-8.21,-47.22,;-6.88,-46.45,;-6.87,-44.91,;-8.22,-48.76,;-9.46,-49.67,;-8.98,-51.13,;-7.45,-51.12,;-6.42,-52.26,;-4.91,-51.94,;-4.44,-50.47,;-5.47,-49.34,;-6.97,-49.66,;-6.86,-40.3,;-8.19,-39.53,;-5.52,-39.53,;2.45,-42.67,;3.79,-41.91,)| | ||
| Structure | 
| ||