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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359137 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | >25000±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
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| BDBM50359137 | |||
| n/a | |||
| Name | BDBM50359137 | ||
| Synonyms: | CHEMBL1922821 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H34F2N4O2 | ||
| Mol. Mass. | 520.6134 | ||
| SMILES | NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1c(F)cccc1F |(8.48,-39.47,;9.81,-40.25,;11.14,-39.48,;9.8,-41.79,;8.47,-42.55,;8.47,-44.09,;7.13,-44.85,;7.12,-46.39,;8.45,-47.16,;9.79,-46.4,;9.8,-44.85,;8.45,-48.7,;7.21,-49.61,;7.69,-51.08,;9.22,-51.07,;10.25,-52.21,;11.75,-51.89,;12.22,-50.42,;11.19,-49.28,;9.7,-49.61,;11.14,-42.56,;11.12,-44.1,;12.45,-44.88,;13.79,-44.12,;13.79,-42.57,;12.46,-41.79,;15.11,-44.89,;15.1,-46.43,;16.45,-44.13,;17.78,-44.91,;19.12,-44.15,;19.12,-42.62,;17.79,-41.85,;20.45,-41.86,;21.79,-42.63,;21.78,-44.18,;20.44,-44.94,;20.43,-46.48,)| | ||
| Structure | 
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