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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359138 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 38±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
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| BDBM50359138 | |||
| n/a | |||
| Name | BDBM50359138 | ||
| Synonyms: | CHEMBL1922822 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H34F2N4O2 | ||
| Mol. Mass. | 520.6134 | ||
| SMILES | NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1ccc(F)c(F)c1 |(27.82,-39.36,;29.15,-40.13,;30.49,-39.36,;29.15,-41.67,;27.81,-42.44,;27.81,-43.98,;26.47,-44.74,;26.47,-46.27,;27.8,-47.05,;29.13,-46.28,;29.14,-44.74,;27.79,-48.59,;26.55,-49.5,;27.03,-50.96,;28.56,-50.95,;29.59,-52.09,;31.1,-51.77,;31.57,-50.3,;30.54,-49.17,;29.04,-49.49,;30.48,-42.44,;30.46,-43.99,;31.79,-44.76,;33.13,-44,;33.14,-42.46,;31.8,-41.68,;34.46,-44.78,;34.45,-46.32,;35.8,-44.02,;37.12,-44.8,;38.46,-44.04,;38.46,-42.5,;39.8,-41.74,;41.13,-42.52,;42.47,-41.75,;41.12,-44.06,;42.45,-44.84,;39.79,-44.82,)| | ||
| Structure | 
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