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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | C-C chemokine receptor type 2 | ||
| Ligand | BDBM50359139 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_789638 (CHEMBL1924723) | ||
| IC50 | 12±n/a nM | ||
| Citation |  Lanter, JC; Markotan, TP; Zhang, X; Subasinghe, N; Kang, FA; Hou, C; Singer, M; Opas, E; McKenney, S; Crysler, C; Johnson, D; Molloy, CJ; Sui, Z The discovery of novel cyclohexylamide CCR2 antagonists. Bioorg Med Chem Lett21:7496-501 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| C-C chemokine receptor type 2 | |||
| Name: | C-C chemokine receptor type 2 | ||
| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 41932.32 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P41597 | ||
| Residue: | 374 | ||
| Sequence: |
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| BDBM50359139 | |||
| n/a | |||
| Name | BDBM50359139 | ||
| Synonyms: | CHEMBL1922823 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H34F2N4O2 | ||
| Mol. Mass. | 520.6134 | ||
| SMILES | NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1cc(F)cc(F)c1 |(46.45,-37.78,;47.78,-38.55,;49.12,-37.78,;47.78,-40.09,;46.44,-40.86,;46.44,-42.4,;45.1,-43.16,;45.1,-44.69,;46.43,-45.47,;47.76,-44.7,;47.77,-43.16,;46.42,-47.01,;45.18,-47.92,;45.66,-49.38,;47.19,-49.37,;48.22,-50.51,;49.72,-50.19,;50.2,-48.72,;49.16,-47.59,;47.67,-47.91,;49.11,-40.86,;49.09,-42.41,;50.42,-43.18,;51.76,-42.42,;51.76,-40.88,;50.43,-40.1,;53.09,-43.2,;53.07,-44.74,;54.42,-42.44,;55.75,-43.22,;57.09,-42.46,;57.09,-40.92,;58.42,-40.16,;58.43,-38.62,;59.76,-40.94,;59.75,-42.48,;61.08,-43.26,;58.41,-43.24,)| | ||
| Structure | 
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