| Reaction Details |
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 | Report a problem with these data |
| Target | NADPH oxidase 5 |
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| Ligand | BDBM50359529 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_792880 (CHEMBL1931065) |
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| Ki | 475±n/a nM |
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| Citation |  Gaggini, F; Laleu, B; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors. Bioorg Med Chem19:6989-99 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NADPH oxidase 5 |
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| Name: | NADPH oxidase 5 |
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| Synonyms: | NOX5 | NOX5_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 86463.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_792880 |
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| Residue: | 765 |
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| Sequence: | MNTSGDPAQTGPEGCRGTMSAEEDARWLRWVTQQFKTIAGEDGEISLQEFKAALHVKESF
FAERFFALFDSDRSGTITLQELQEALTLLIHGSPMDKLKFLFQVYDIDVCARQGASAGTE
WGAGAGPHWASSPLGTGSGSIDPDELRTVLQSCLRESAISLPDEKLDQLTLALFESADAD
GNGAITFEELRDELQRFPGVMENLTISAAHWLTAPAPRPRPRRPRQLTRAYWHNHRSQLF
CLATYAGLHVLLFGLAASAHRDLGASVMVAKGCGQCLNFDCSFIAVLMLRRCLTWLRATW
LAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTVNFVLQAQAEASPFQFWELLLTTRPGI
GWVHGSASPTGVALLLLLLLMFICSSSCIRRSGHFEVFYWTHLSYLLVWLLLIFHGPNFW
KWLLVPGILFFLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRPPFFHYRPGDYLYLN
IPTIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLYESFKASDPLGRGSKRLSRSVT
MRKSQRSSKGSEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASIL
QSIMYRHQKRKHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSFEWFVSLLTKLEMDQ
AEEAQYGRFLELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSITGLQTRTQPGRPDW
SKVFQKVAAEKKGKVQVFFCGSPALAKVLKGHCEKFGFRFFQENF
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| BDBM50359529 |
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| n/a |
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| Name | BDBM50359529 |
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| Synonyms: | CHEMBL1927150 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H20Cl2N4O2 |
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| Mol. Mass. | 455.337 |
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| SMILES | Clc1cccc(CN2CCCn3c(C2)c2c(cc3=O)[nH]n(-c3ccccc3Cl)c2=O)c1 |
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| Structure | 
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