Reaction Details |
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Target | MAP kinase-activated protein kinase 2 |
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Ligand | BDBM50360567 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_795362 (CHEMBL1937262) |
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EC50 | 1300±n/a nM |
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Citation | Oubrie, A; Kaptein, A; de Zwart, E; Hoogenboom, N; Goorden, R; van de Kar, B; van Hoek, M; de Kimpe, V; van der Heijden, R; Borsboom, J; Kazemier, B; de Roos, J; Scheffers, M; Lommerse, J; Schultz-Fademrecht, C; Barf, T Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series. Bioorg Med Chem Lett22:613-8 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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MAP kinase-activated protein kinase 2 |
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Name: | MAP kinase-activated protein kinase 2 |
Synonyms: | MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 45579.87 |
Organism: | Homo sapiens (Human) |
Description: | P49137 |
Residue: | 400 |
Sequence: | MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAII
DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRI
VDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSI
NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKY
DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKM
LIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSAL
ATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
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BDBM50360567 |
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n/a |
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Name | BDBM50360567 |
Synonyms: | CHEMBL1933175 |
Type | Small organic molecule |
Emp. Form. | C24H22F3N5O2 |
Mol. Mass. | 469.459 |
SMILES | FC(F)(F)c1ccc(cc1)C(=O)Nc1cc(ccn1)-c1cc2c([nH]1)C1(CCNCC1)CNC2=O |
Structure |
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