Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50364313 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_804628 (CHEMBL1953150) |
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Ki | 37±n/a nM |
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Citation | Tripathy, R; McHugh, RJ; Bacon, ER; Salvino, JM; Morton, GC; Aimone, LD; Huang, Z; Mathiasen, JR; DiCamillo, A; Huffman, MJ; McKenna, BA; Kopec, K; Lu, LD; Qian, J; Angeles, TS; Connors, T; Spais, C; Holskin, B; Duzic, E; Schaffhauser, H; Rossé, GC Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT6 receptor antagonist showing activity in rat social recognition test. Bioorg Med Chem Lett22:1421-6 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50364313 |
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n/a |
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Name | BDBM50364313 |
Synonyms: | CHEMBL1949765 |
Type | Small organic molecule |
Emp. Form. | C18H19NO3S |
Mol. Mass. | 329.413 |
SMILES | Cc1cccc(c1)S(=O)(=O)c1ccc2[C@@H]3CCNC[C@@H]3Oc2c1 |r| |
Structure |
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