| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50281608 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_61436 (CHEMBL671409) |
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| IC50 | 2430±n/a nM |
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| Citation |  Jaen, JC; Caprathe, BW; Wise, LD; Meltzer, LT; Pugsley, TA; Huffner, TG Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385 Bioorg Med Chem Lett3:639-644 (1993) Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 50931.60 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P61169 |
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| Residue: | 444 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFMKILHC
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| BDBM50281608 |
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| n/a |
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| Name | BDBM50281608 |
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| Synonyms: | 1-Pyridin-2-yl-4-(4-thiophen-2-yl-cyclohex-3-enylmethyl)-piperazine | CHEMBL349994 | PD-135146 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N3S |
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| Mol. Mass. | 339.498 |
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| SMILES | C(C1CCC(=CC1)c1cccs1)N1CCN(CC1)c1ccccn1 |c:4| |
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| Structure | 
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