| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
|---|
| Ligand | BDBM50282611 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_34647 (CHEMBL648938) |
|---|
| IC50 | 4±n/a nM |
|---|
| Citation |  Dorsch, D; Mederski, WW; Beier, N; Lues, I; Minck, K; Schelling, P (6-oxo-3-pyridazinyl)-benzimidazoles as potent angiotensin II receptor antagonists Bioorg Med Chem Lett4:1297-1302 (1994) Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Type-1 angiotensin II receptor |
|---|
| Name: | Type-1 angiotensin II receptor |
|---|
| Synonyms: | AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 41009.15 |
|---|
| Organism: | RABBIT |
|---|
| Description: | ANGIOTENSIN AT1 AGTR1 RABBIT::P34976 |
|---|
| Residue: | 359 |
|---|
| Sequence: | MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
|
|
|
|---|
| BDBM50282611 |
|---|
| n/a |
|---|
| Name | BDBM50282611 |
|---|
| Synonyms: | (3-{2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazol-5-yl}-4-methyl-6-oxo-5,6-dihydro-4H-pyridazin-1-yl)-acetic acid methyl ester | CHEMBL284704 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C32H30N8O3 |
|---|
| Mol. Mass. | 574.6324 |
|---|
| SMILES | COC(=O)CN1N=C(C(C)CC1=O)c1ccc2nc(C3CC3)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2c1 |c:6| |
|---|
| Structure | 
|
|---|
Search and Browse
