Reaction Details |
| Report a problem with these data |
Target | Neprilysin |
---|
Ligand | BDBM50291559 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_144318 |
---|
IC50 | 0.600000±n/a nM |
---|
Citation | De Lombaert, S; Stamford, LB; Blanchard, L; Tan, J; Hoyer, D; Diefenbacher, CG; Wei, D; Wallace, EM; Moskal, MA; Savage, P; Jeng, AY Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11 Bioorg Med Chem Lett7:1059-1064 (1997) Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Neprilysin |
---|
Name: | Neprilysin |
Synonyms: | Atriopeptidase | CALLA | CD_antigen=CD10 | Common acute lymphocytic leukemia antigen | EPN | Enkephalinase | MME | NEP | NEP_HUMAN | Neutral Endopeptidase (NEP) | Neutral endopeptidase | Neutral endopeptidase 24.11 |
Type: | Enzyme |
Mol. Mass.: | 85505.38 |
Organism: | Homo sapiens (Human) |
Description: | P08473 |
Residue: | 750 |
Sequence: | MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSS
DCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKD
VLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGA
SWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKE
ACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLY
NKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILT
KYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNME
NAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERI
GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAA
VVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKD
GDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYR
AYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII
GTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
|
|
|
BDBM50291559 |
---|
n/a |
---|
Name | BDBM50291559 |
Synonyms: | CHEMBL268473 | {2-Benzo[1,3]dioxol-5-yl-1-[(S)-2-biphenyl-4-yl-1-(1H-tetrazol-5-yl)-ethylamino]-ethyl}-phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C24H24N5O5P |
Mol. Mass. | 493.4516 |
SMILES | OP(O)(=O)C(Cc1ccc2OCOc2c1)N[C@@H](Cc1ccc(cc1)-c1ccccc1)c1nnn[nH]1 |
Structure |
|