| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
|---|
| Ligand | BDBM22418 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_202137 (CHEMBL808126) |
|---|
| Ki | 413±n/a nM |
|---|
| Citation |  Tamiz, AP; Smith, MP; Enyedy, I; Flippen-Anderson, J; Zhang, M; Johnson, KM; Kozikowski, AP Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors. Bioorg Med Chem Lett10:1681-6 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent serotonin transporter |
|---|
| Name: | Sodium-dependent serotonin transporter |
|---|
| Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 70168.43 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | P31652 |
|---|
| Residue: | 630 |
|---|
| Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
|
|
|
|---|
| BDBM22418 |
|---|
| n/a |
|---|
| Name | BDBM22418 |
|---|
| Synonyms: | Cocaine | Cocaine (-) | methyl (1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate | methyl (1R,2R,3S,5S)-8-methyl-3-[(phenylcarbonyl)oxy]-8-azabicyclo[3.2.1]octane-2-carboxylate |
|---|
| Type | n/a |
|---|
| Emp. Form. | C17H21NO4 |
|---|
| Mol. Mass. | 303.3529 |
|---|
| SMILES | [H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)c1ccccc1)C(=O)OC)N2C |TLB:18:6:22:3.2| |
|---|
| Structure | 
|
|---|
Search and Browse
