| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 1 |
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| Ligand | BDBM50002369 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_90437 (CHEMBL697426) |
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| Ki | 177±n/a nM |
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| Citation |  Baker, SR; Bleakman, D; Ezquerra, J; Ballyk, BA; Deverill, M; Ho, K; Kamboj, RK; Collado, I; Domínguez, C; Escribano, A; Mateo, AI; Pedregal, C; Rubio, A 4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists. Bioorg Med Chem Lett10:1807-10 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, kainate 1 |
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| Name: | Glutamate receptor ionotropic, kainate 1 |
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| Synonyms: | GLUR5 | GRIK1 | GRIK1_HUMAN | Glutamate Receptor | Glutamate kainate | Glutamate receptor ionotropic kainate | Glutamate receptor ionotropic kainate 1 | Glutamate receptor, ionotropic kainate 1 | Glutamate-Kainate | Glutamate-Kainate, GluR5 | Grik1 protein | hmglur5 flipr |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 103984.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P39086 |
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| Residue: | 918 |
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| Sequence: | MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF
AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ
SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS
TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL
KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME
RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF
MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGI
WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL
DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK
VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT
PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL
IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM
WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG
VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI
VLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECG
KLIREERGIRKQSSVHTV
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| BDBM50002369 |
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| n/a |
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| Name | BDBM50002369 |
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| Synonyms: | (2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid | (3S,4R)-3-(carboxymethyl)-4-(prop-1-en-2-yl)-L-proline | CHEMBL275040 | Digenin | Digensaeure | Helminal | Kainate | Kainsaeure | L-alpha-kainic acid | alpha-Kainic acid | digenic acid | kainic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C10H15NO4 |
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| Mol. Mass. | 213.2304 |
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| SMILES | CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O |r| |
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| Structure | 
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