Ki Summary

Reaction Details

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Target

Transporter

Ligand

BDBM50107092

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_143108

>100000±n/a nM

Citation

Cao, J; Husbands, SM; Kopajtic, T; Katz, JL; Newman, AH [3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter. Bioorg Med Chem Lett11:3169-73 (2001) [PubMed]

More Info.:

Get all data from this article, Assay Method

Transporter

Name:

Transporter

Synonyms:

Monoamine transporters; Norepininephrine & dopamine | Norepinephrine Monoamine transporters

Type:

PROTEIN

Mol. Mass.:

66787.87

Organism:

Rattus norvegicus

Description:

ChEMBL_1463061

Residue:

597

Sequence:

MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLF
YMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLN
LPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDI
GLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNG
INAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTIN
CVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFL
MLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLT
LLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLL
FVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAY
GITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI

BDBM50107092

n/a

Name

BDBM50107092

Synonyms:

(3-{(3R,5R)-4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-dimethyl-piperazin-1-yl}-propyl)-bis-(4-fluoro-phenyl)-amine | (3-{4-[2-(3,4-Dichloro-phenyl)-ethyl]-3,5-dimethyl-piperazin-1-yl}-propyl)-bis-(4-fluoro-phenyl)-amine | CHEMBL86830

Type

Small organic molecule

Emp. Form.

C29H33Cl2F2N3

Mol. Mass.

532.495

SMILES

C[C@@H]1CN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)C[C@@H](C)N1CCc1ccc(Cl)c(Cl)c1

Structure