Reaction Details |
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Target | Reverse transcriptase/RNaseH |
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Ligand | BDBM50096654 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_140633 |
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IC50 | 26±n/a nM |
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Citation | Corbett, JW; Kresge, KJ; Pan, S; Cordova, BC; Klabe, RM; Rodgers, JD; Erickson-Viitanen, SK Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase. Bioorg Med Chem Lett11:309-12 (2001) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase/RNaseH |
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Name: | Reverse transcriptase/RNaseH |
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
Type: | PROTEIN |
Mol. Mass.: | 65229.15 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_1473730 |
Residue: | 566 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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BDBM50096654 |
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n/a |
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Name | BDBM50096654 |
Synonyms: | 3-[3-Cyclopropyl-1-(pyridin-2-ylmethoxy)-1-trifluoromethyl-prop-2-ynyl]-1H-pyridin-2-one | CHEMBL104349 |
Type | Small organic molecule |
Emp. Form. | C18H15F3N2O2 |
Mol. Mass. | 348.3191 |
SMILES | FC(F)(F)C(OCc1ccccn1)(C#CC1CC1)c1ccc[nH]c1=O |
Structure |
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