| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aromatase |
|---|
| Ligand | BDBM50014324 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_51211 |
|---|
| Ki | 29±n/a nM |
|---|
| Citation |  Cole, PA; Robinson, CH Mechanism and inhibition of cytochrome P-450 aromatase. J Med Chem33:2933-42 (1990) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aromatase |
|---|
| Name: | Aromatase |
|---|
| Synonyms: | Arom | Aromatase | CP19A_RAT | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P450 19A1 | Estrogen synthetase | P-450AROM |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 58418.09 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_51211 |
|---|
| Residue: | 508 |
|---|
| Sequence: | MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLI
SHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKR
GLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTD
NSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWL
YRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCI
LEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFI
NESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEK
NVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLH
LDEDSPIVEIIFRHIFNTPFLQCLYISL
|
|
|
|---|
| BDBM50014324 |
|---|
| n/a |
|---|
| Name | BDBM50014324 |
|---|
| Synonyms: | 5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine | 5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine(LY56110) | CHEMBL29669 | LY-56110 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H12Cl2N2 |
|---|
| Mol. Mass. | 315.197 |
|---|
| SMILES | Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1cncnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
